Mineralocorticoid Receptor Overexpression in Embryonic Stem Cell
نویسندگان
چکیده
Damien Le Menuet , Mathilde Munier, Geri Meduri, Say Viengchareun, and Marc 3 Lombès 4 5 1INSERM, U693, Le Kremlin-Bicêtre, F-94276, France; 6 2Univ Paris-Sud 11, Faculté de Médecine Paris-Sud, UMR-S693, Le Kremlin-Bicêtre, F7 94276, France; 8 3Service de Génétique Moléculaire, Pharmacogénétique et Hormonologie, Le Kremlin9 Bicêtre Assistance Publique-Hôpitaux de Paris, Hôpital de Bicêtre F-94275, France; 10 4Service d’Endocrinologie et Maladies de la Reproduction, Assistance Publique-Hôpitaux 11 de Paris, Hôpital de Bicêtre, Le Kremlin-Bicêtre, F-94275, France. 12 13
منابع مشابه
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Background: Fibronectin type III domain-containing 5 proteins (Fndc5), an exercise hormone, formerly known as peroxisomal protein that was cloned in 2002. Transcript profile analysis of Fndc5 revealed high degree of expression in heart, skeletal muscle and brain. Our recent studies indicated a significant increase (approximately 10 folds) in mRNA level of Fndc5 when mouse embryonic stem cells w...
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4 Service d’Endocrinologie et Maladies de la Reproduction, Assistance Publique-Hôpitaux de Paris, 14 Hôpital de Bicêtre, Le Kremlin-Bicêtre, F-94275, France. 15 16 Corresponding author’s address: Marc Lombès, INSERM U693, Faculté de Médecine Paris-Sud 11, 17 63, rue Gabriel Péri, 94276 Le Kremlin-Bicêtre Cedex France. E-mail: [email protected]. Tel : 18 +33 1 49 59 67 09. Fax : + 33 1 49 59...
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AIMS Cardiac mineralocorticoid receptor (MR) activation triggers adverse cardiovascular events that could be efficiently prevented by mineralocorticoid antagonists. To gain insights into the pathophysiological role of MR function, we established embryonic stem (ES) cell lines from blastocysts of transgenic mice overexpressing the human MR driven by its proximal P1 or distal P2 promoter and pres...
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تاریخ انتشار 2010